Gallery

Alpha/Beta versions 0.7 to 0.9 (pre-release)


Kannan, N., A.F. Neuwald and S. S. Taylor. 2007. Analogous regulatory sites within the αC-β4 loop regions of ZAP70 tyrosine kinase and AGC kinases. Biochimica et Biophysica Acta (BBA)-Proteins & Proteomics 1784(1):27-32.


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AGC protein kinases

Kannan, N. Haste, N. Taylor, S. S. and Neuwald, A.F. 2007. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A. 104(4): 1272–1277.


(See also: Kannan, N. Neuwald, A. F. and Taylor, S. S. 2007. Analogous regulatory sites within the αC-β4 loop regions of ZAP-70 tyrosine kinase and AGC kinases. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 1774(11): 000–000.)

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Eukaryotic Protein Kinases

Kannan, N. & Neuwald, A.F. 2005. Did protein kinase regulatory mechanisms evolve through elaboration of a simple structural component? Journal of Molecular Biology 351(5): 956–972.

DNA Clamp Loaders
(earlier, in depth analyses)

Neuwald, A.F. 2006. Hypothesis: bacterial clamp loader AAA+ ATPase activation through DNA-dependent repositioning of the catalytic base and of a trans-acting catalytic threonine. Nucleic Acids Research 34(18): 5280-5290.


Neuwald, A.F. 2005. Evolutionary clues to eukaryotic DNA clamp-loading mechanisms: analysis of the functional constraints imposed on replication factor C AAA+ ATPases. Nucleic Acids Research 33:3614-3628.